As the pandemic continues, the world at large has had to take a critical and sobering look at its current health status; more and more, people are seeking ways to optimize their health in the short-term while protecting against acute infection and preventing future disease. This episode of Pathways to Well-Being is a functional medicine year in review with IFM Director of Medical Education Dan Lukaczer, ND, IFMCP, and IFM Director of Medical Education Initiatives Robert Luby, MD, IFMCP. Several topics, including restricted feeding regimens, lifestyle and biological aging, and COVID-19, were prominent in the clinical research during 2021. Drs. Lukaczer and Luby discuss how these advances may highlight clinical windows of opportunities for intervention and present novel therapeutics that may confer a protective role in lifelong health.