A team of scientists led by members of Shanghai Institute of Stem Cell Research and Clinical Translation at the Shanghai East Hospital’s School of Medicine, Tongji University, report on some disturbing trends associated with mass COVID-19 vaccinations across multiple nations with inactivated SARS-CoV-2 vaccines from China. 

Led by corresponding authors Zhongmin Liu, Congrong Wang, and Yi E. Sun, the authors report that the vaccination program is impacting persons above and beyond simply generating neutralizing antibodies.  They report seemingly constant changes in hemoglobin A1c, serum sodium and potassium levels, not to mention coagulation profiles as well as kidney functions in 100% healthy study volunteers post a jab with inactive vaccines (e.g., Sinopharm, etc.). However, the medical researchers also discovered in their study that comparable modifications have been observed in COVID-19 patients, suggesting vaccination “mimicked an infection.”  After conducting single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) looking at the samples prior to and after 28 days post the first jab the study authors report numerous and uniform changes in gene expression of several immune cell types.  Among other findings the authors note lower counts of CD8+ T cells, mediators of adaptive immunity, as well as more classic monocyte contents. Additional sequences (snRNA-seq) also exhibited greater NF-kB signaling (associated with production of cytokine and inflammation generally) as well as lower amounts of type I interferon responses, confirmed via biological assays, also known to occur post COVID-19 infection with severe symptoms. The study authors suggest potentially adverse impacts from the mass vaccination program, recommending caution when vaccinating persons with pre-existing conditions such as diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders. 

Study Type

Longitudinal Follow up study

The Vaccine Under Investigation

SARS-CoV-2 vaccine (Vero Cell) inactivated by the Beijing Institute of Biological Products Co. Ltd. (Sinopharm) Subscribe to the Trialsitenews “COVID-19” ChannelNo spam – we promise


The authors report in Nature, Cell Discover indicate that based on their observations inoculation with inactivated COVID-19 vaccines that “in addition to stimulating the generation of neutralizing antibodies” the products also “influenced various health indicators including those related to diabetes, renal dysfunction, cholesterol metabolism, coagulation problems, electrolyte imbalance” in such a way as it almost seems like actual SARS-CoV-, the virus behind COVID-19 is triggered by the inactivated vaccines.

Dramatic Changes Post Vaccination

For example, the authors from China used sophisticated sequencing methods such as scRNA-seq of the PBMCs from vaccine study volunteers pre-and post- the jab finding “dramatic changes in immune cell gene expression, not only echoing some of the clinical laboratory measures but also suggestive of increased NF-kB-elated inflammatory responses” occurring in classical monocytes. Post-vaccination, the sequencing observation suggests impacts to “the gene set positively contributing to MVS scores, also known to be associated with severe symptom development” and highly expressed in monocytes. 

Meanwhile, the authors point out that while type 1 interferon (IFN-α/β) are considered beneficial against SARS-CoV-2 infection, they were actually “downregulated after vaccination.”


Mass vaccination may be damaging innocent volunteers during study and in association with mass vaccination as the inactivated vaccines, in addition to eliciting neutralizing antibody responses, could be seriously compromising people’s immune systems.

The Academic Medical Center

The study leads to work out of the Shanghai East Hospital, School of Medicine, Tongji University. Based in Pudong, Shanghai, this teaching hospital is affiliated with Tongji University. Founded in 1920, the Shanghai East Hospital and the Shanghai Tongji University School of Medicine cover two campuses including 61 clinical and technical departments and offices.

A large hospital with 2,000 beds, what’s known as the “South-Campus” is known for medical procedures, disease prevention, and medical education as well as clinical research.  Combined both campuses employ 2,800 staff and at least 400 attending physicians. This complex serves 3 million walk-in patients as well as emergency room patients per annum—including about 4000 international patients.

Lead Research/Investigator

Zhongmin Liu,  Shanghai Institute of Stem Cell Research and Clinical Translation at the Shanghai East Hospital’s School of Medicine, Tongji University

Yi E. Sun,  Shanghai Institute of Stem Cell Research and Clinical Translation at the Shanghai East Hospital’s School of Medicine, Tongji University

Congrong Wang, Shanghai Institute of Stem Cell Research and Clinical Translation at the Shanghai East Hospital’s School of Medicine, Tongji University; Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Department of Endocrinology & Metabolism

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